Title: Multimodal fusion of radio-pathology and proteogenomics identify integrated glioma subtypes with prognostic and therapeutic opportunities

Keypoints: 

• Question- Can integrated multimodel data from radio- histology and proteogenomics refine three subgroups in IDH-wildtype gliomas with prognostic and therapeutic opportunities?

• Findings- The multifarious biological and clinical peculiarities of the multimodal fusion framework (MOFS) taxonomy improve the understanding of glioblastoma (GBM) heterogeneity and facilitate clinical stratification and individualized management. STRAP is significantly associated with the prognosis and proliferative phenotype of MOFS2 patients, thereby representing a potential therapeutic target for this subtype. The abundance of stroma serves as a vital prognostic index, which could reassess the survival risk of MOFS3 patients. To further facilitate researchers and clinical practitioners, we developed the MRI-based classifier for predicting MOFS subtypes. We believe this high-resolution taxonomy could facilitate more effective management of patients with IDH wild-type GBM.

• Meaning - This study proposes a novel MOFS, enabling a more comprehensive understanding of the complexity of IDH-wildtype gliomas and providing new perspectives for personalized management and precision therapy.

Title: SERS-guided precision resection combined with photothermal-immunotherapy for glioblastoma recurrence prevention

Keypoints: 

• Question - How to perform precise resection and prevent recurrence of glioblastoma with a multifunctional nanoplatform?

• Findings - The study constructs SPIT probes, which use gold nanostars (AuNS) as the core, load 4-mercaptobenzonitrile (4-MBN) as the Raman reporter molecule, and are coated with macrophage membranes genetically overexpressing SIRPα variants. It precisely guides intraoperative tumor resection through SERS signals, ablates residual micro-lesions using the photothermal effect of AuNS, and simultaneously blocks the CD47-SIRPα pathway via overexpressed SIRPα variants to enhance macrophage-mediated tumor phagocytosis. The three functions synergistically inhibit glioblastoma recurrence.

• Meaning - The study proposes a "three-in-one" nanoplatform, which penetrates the blood-brain barrier via macrophage membranes, integrates SERS guidance, photothermal and immunotherapy, and shows clinical translation potential.