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Functional properties of depression and obsessive-compulsive disorder.

Topic:  Functional properties of depression and obsessive-compulsive disorder


Moderator: Yuxin Zhang, Post.doc


Speaker 1: Lisha Zhang, Ph.D. Candidate
Supervisor: Prof. Qiyong Gong

Speaker 2: Yufei Chen, M.M. Candidate
Supervisor: Prof. Fei Li


Date: 2/12/2024, 14:00

Location: The lab of HMRRC (10011, the 8th Teaching Building)

Speaker 1: Lisha Zhang , Ph.D. Candidate

Title: Shared and Unique Changes in Brain Connectivity Among Depressed Patients After Remission With Pharmacotherapy Versus Psychotherapy

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Keypoints：

  • Question: 1) What changes are common across patients who achieve remission, irrespective of their specific treatment? 2) What changes are unique to patients who achieve remission with CBT versus with an antidepressant medication? 3) Do the patterns of patients who remitted after treatment differ from those of healthy, never-depressed control subjects?
  • Findings: 1) All remitters, regardless of treatment, showed reduced rsFC between the AN and the somatomotor network, particularly in the medial M1 area related to the trunk section of Penfield's homunculus. 2) The two treatments differed significantly in their effects on patterns of rsFC of the ECN, AN, and SN. Most notably, CBT remitters had increased ECN connectivity with attention regions, aligning with CBT's proposed brain mechanisms, unlike medication remitters. 3) CBT remitters showed greater connectivity of the AN to the posterior insula and the SN to the precuneus and visual regions, while medication remitters had reduced connectivity in these areas.
  • Meaning: 1) Remission from major depression via CBT or medication shows treatment-specific changes in rsFC. 2) Reduced affective network connectivity with motor systems is important for remission in both treatments. 

Speaker 2: Yufei Chen, M.M. Candidate

Title: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

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Keypoints：

  • Question: 1) Is there any group difference in whole-brain functional connectivity, at the either regional or network level, between patients with obsessive-compulsive disorder (OCD) and healthy controls (HC)? 2) Is there any group difference in whole-brain functional connectivity between subgroups of participants with specific demographic and clinical characteristics (i.e. age groups, severity of symptoms, age of onset and medication status)? 3) Could functional connectivity serve as a biomarker to identify patient at the individual level using machine learning analysis?

  • Findings: 1) The mega-analyses revealed widespread abnormalities in functional connectivity in OCD, with global hypo-connectivity, mainly with the sensorimotor network, and few hyper-connectivity, mainly with the thalamus. 2) No significant case-control differences were detected except for comparisons between adult samples, and those between late-onset, high-severity and medicated patients versus HC. 3) Overall classification performance was poor though significant, with area-under-the-receiver-operating-characteristic curve (AUC) scores ranging between 0.567 and 0.673 across the different measures, which is insufficient for clinical application.

  • Meaning: This is the largest functional connectivity analysis in OCD conducted to date using a mega-analytic approach by pooling individual data across studies. This study also investigated differences between subgroups of participants with specific demographical and clinical characteristics. Finally, this research obtained classification performances of functional connectivity.


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