Neurodegenerative Diseases and Mental Health in the Elderly .||学术交流|最新动态| 华西磁共振研究中心

Neurodegenerative Diseases and Mental Health in the Elderly .

Topic: Neurodegenerative Diseases and Mental Health in the Elderly

Moderator: Qiao Wen, Post.doc

Speaker 1: Baoshuai Zhang, Ph.D. Candidate

Supervisor: Prof. Qiyong Gong

Speaker 2: Shihan Tian, M.Med. Candidate

Supervisor: Prof. Na Hu; Prof. Xiaohe Tian

Date: 25/11/2024, 14:00

Location: The lab of HMRRC (10011, the 8th Teaching Building)

Speaker 1: Baoshuai Zhang, Ph.D. Candidate

Title: Multimodal brain connectome-based prediction of suicide risk in people with late-life depression

Keypoints：

Question: Could multimodal brain connectivity capture individual differences in suicide risk among latelife depression patients?
Hypothesis: The functional and structural network would predict individual suicide risk scores among LLD patients using several suicide behavior questionnaires.
Methods: To predict the suicide risk using functional connectivity (FC) and structural connectivity (SC) , the connectome-based predictive modelling (CPM) method was used. To formally test the predictive strength of the identified FC and SC profiles, a machine learning method was employed to derive the prediction accuracy of the models.
Meaning: The brain connectome models can predict suicide risk in LLD patients. The FC and SC profiles improved the classification accuracy when distinguishing LLD patients with higher suicide risk from those with lower suicide risk.

Speaker 2: Shihan Tian, M.Med. Candidate

Title: Imaging beta amyloid aggregation and iron accumulation in Alzheimer's disease using quantitative susceptibility mapping MR

Keypoints：

Question: Can QSM MR imaging noninvasively monitor beta-amyloid aggregation and iron accumulation and aid in the diagnosis of Alzheimer's disease?
Findings: The study demonstrated in a phantom that beta amyloid was diamagnetic and can generate strong contrast on susceptibility maps. Based on this, it is further shown both in vivo and ex vivo that magnetic susceptibility mapping could be used to detect accumulation of amyloid plaques in AD mouse models. Finally, the authors demonstrated that the diamagnetic susceptibility of beta amyloid can also be observed in brain specimens of AD patients.
Meaning: The ability to assess beta amyloid aggregation non-invasively with QSM MR imaging may aid the diagnosis of Alzheimer's disease.

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